Yes. Flavors for Splizz are Red Grapefruit and Orange.

Yes. Splizz dissolve in water for fizzy, refreshing multi-symptom pain relief you can hear, see and feel immediately. 

The best temperature is room temperature. Cold water will slow down dissolution and warm water can make it foam excessively.

Splizz contains three active ingredients in each effervescent tablet: Acetaminophen 250mg (Pain Reliever), Aspirin 250mg (Pain Reliever) and Caffeine 65mg (Pain Reliever Aid). 

Alka-Seltzer contains anhydrous citric acid (antacid) and sodium bicarbonate (antacid). It is an antacid. Splizz contains Acetaminophen (pain reliever), Aspirin (pain reliever) and Caffeine (pain reliever aid). It is an internal analgesic. 

There are multiple advantages to using Splizz effervescent tablets. In short: the medicine dissolves fast and goes to work instantly. Because the medicines in Splizz effervescents are in solution prior to ingestion, they do not require time to dissolve in the stomach like similar active ingredients taken in a tablet form.

Splizz is indicated for the temporary relief of minor aches and pains associated with:

The common cold

Headache

Toothache

Muscular aches

Backache

Minor pain of arthritis

Premenstrual and menstrual cramps

We recommend that you discard any expired Splizz product. It won’t be harmful if ingested, but it may not be as effective in relieving your pain.

As with any drug or dietary supplement, if you are pregnant or breast-feeding, ask your health professional before using any Splizz product.

Caffeine has been an ingredient in both OTC and prescription drug products for many decades. Medical research has demonstrated that caffeine is a safe and effective addition to the combination of acetaminophen and aspirin in medications for relief of pain when used at the appropriate dose. The acetaminophen-aspirin-caffeine combination is approved and clinically proven to be effective and well-tolerated for multi-symptom pain relief, but as always, you should follow package directions.

The recommended dose of this product contains about as much caffeine as a cup of coffee. Limit the use of caffeine-containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and, occasionally, rapid heartbeat.

Caffeine has been found to enhance the pain relieving function of aspirin and acetaminophen when used in combination as in Splizz.

Acetaminophen is an effective pain reliever and fever reducer. Acetaminophen is thought to relieve mild to moderate pain by elevating your body’s overall pain threshold. It is also thought to lower your fever by helping your body eliminate excess heat.

The FDA has determined that acetaminophen is safe for most people to use, when taken as directed. Take acetaminophen and all other medications according to the package directions. For further information or to discuss personal health concerns, please consult your pharmacist or physician.

With a 120-year track record of safety and efficacy, aspirin is one of the most extensively studied pain relievers in history. Splizz Aspirin is safe and effective for pain relief when used according to label directions. If you have any questions about whether aspirin is right for you, your condition or the medications you are taking, please talk to your doctor.

Splizz contains acetaminophen. Severe liver damage may occur if you take 3 or more alcoholic drinks every day while using Splizz.

The package label of all OTC pain medicines advise consumers to “stop use and ask a doctor if … pain gets worse or lasts more than 10 days…” This warning is necessary so that patients will seek appropriate medical attention if needed.

Splizz should not be used with other products containing acetaminophen. Always read and follow the label. If you are under a doctor’s care for any serious condition, or are taking any other drugs, you should talk to your doctor if you want to know more or have other questions.

If you are taking any other drugs, including herbal supplements, you should talk to your doctor or pharmacist if you want to know more or have other questions. Always use the product as directed and read the label.

Use of Splizz with other pain relievers (such as acetaminophen, aspirin, ibuprofen, naproxen sodium, ketoprofen or prescription pain relievers) is not recommended, unless directed by your doctor.

Do not use Splizz with any other products containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.

If you are under a doctor's care for any serious condition, or are taking any other drugs, you should talk to your doctor if you want to know more or have other questions.

Splizz is safe and effective when used as directed. Each person’s particular condition is unique. 

Please call your doctor first if you have any questions about whether Splizz is right for you to use. Please read all label directions, instructions, and warnings. If you experience any side effects from taking Splizz, stop taking Splizz immediately and contact your healthcare provider right away.

If you have any condition that requires a prescription medication, talk with your doctor or pharmacist about using Splizz, or any other pain reliever.

Some headaches are caused or "triggered" in a variety of ways. For some headache sufferers, changes in weather as well as odors, foods, alcoholic beverages, stress, and other factors may "trigger" headaches. Some triggers are more common than others — alcohol, sugar, chocolate, fatty foods, and citrus fruits are among them.

Approximately 90% of all headaches are classified as tension-type (sometimes also referred to as muscle contraction headaches). Another 8% are migraine or cluster headaches. Only 2% are potentially more serious — that is, secondary to an underlying illness or other medical condition. He should see a doctor for an accurate diagnosis of his condition. See When To See a Professional for Your Headaches for tips on choosing a headache specialist.

No. Tension-type headaches, which affect more than three-quarters of all headache sufferers and are five times as frequent as migraines, also can be very painful. They can interfere with job productivity, family life, and a general sense of well-being.

Patients suffering from mixed headaches experience various combinations of tension-type headaches and migraines. Often a person who has suffered for years from one type of headache will begin to experience the other as well. This phenomenon, as well as other relationships between tension headaches and migraines that research has shown recently, has led many researchers to believe that the two forms of headache may share a common mechanism in the brain.

It may be. Changes in the weather, usually from good to bad, can trigger a migraine or other type of headache. Some migraine sufferers can actually predict their headaches by changes in the weather. Scientists theorize that as a storm front approaches, changes in the barometric pressure affect the headache sufferer, triggering a migraine attack. 

It’s possible. Certain foods — including those that contain tyramine (such as hard cheeses) or nitrites (such as processed meats) — commonly trigger migraine headaches. Chocolate and alcohol (particularly red wine and beer) are also common triggers in some people. So are some fruits, yogurt, MSG, and freshly-baked breads. However, there does not appear to be a causal link between food and tension headaches. So, if you find that giving up a particular food makes your headache go away, chances are you had a migraine.

We don't understand completely what causes the throbbing head or face pain that some people feel when they take a bite of ice cream or swallowing other cold substances. It most likely has to do with the sudden cold shock sent to the warm tissues of the mouth and throat. Sensations of discomfort are then carried by various nerves from the front of the mouth and the back of the throat to other parts of the head, and lasts less than five minutes. Although there is no treatment for these types of headaches, you can avoid them. Eat more slowly and in smaller amounts. Allow ice cream to melt in your mouth before swallowing, this helps cool off the warm tissues in your mouth gradually.

There could be. Headache activity is influenced by fluctuations in the menstrual-related hormones, particularly estrogen and progesterone. This can lead to headaches around the time of menstruation or mid-cycle, during ovulation. Premenstrual headaches, which may strike as migraines or tension-type, afflict 10 million American women.

A migraine headache is a recurring, throbbing pain that usually affects one side of the head, but may affect both sides. Migraine sufferers describe the pain ranging from mild to searing, excruciating, stabbing, and even debilitating. Typically, the pain begins in and around the eye or temple. A migraine attack is usually accompanied by nausea, sensitivity to light (photophobia) and sound (phonophobia), and sometimes vomiting. The pain is often worsened by physical activity, such as mild exercise, bending over, or even changing position suddenly. You should see a doctor for diagnosis.

Many scientists believe that migraine headaches occur when arteries to the brain constrict, 

then dilate, resulting in the throbbing pain of a migraine headache. It isn't known what causes the blood vessels to constrict and dilate, but abnormally low blood levels of a chemical substance called serotonin may trigger the contractions. Migraine attacks can be disabling. More than 80% of migraine sufferers report at least some headache-related disability: 50% or more report mild or moderate disability, such as being unable to work or engage in usual daily activities; and about 30% report severe disability, sometimes requiring bed rest.

Migraine headaches affect approximately 30 million people in the U.S. each year. The majority of them don't currently seek treatment for their migraine pain.

Migraine headaches may first occur at a relatively young age, with the peak onset between eight and 12 years of age among males and between 13 and 17 years of age among females. The peak age for incidence is between 30 and 39 years of age. Migraines may occur less frequently and with less severity after the age of 50.

Migraine headaches are usually characterized by throbbing or pulsing pain on one side of the head. The symptoms of migraine headache sometimes include sensitivity to light or sound, loss of vision, and nausea. Tension headaches typically cause a dull, steady ache above the eyes or in the back of the head. They are usually accompanied by a feeling of tight head pressure and occasional nausea.

The two most prevalent types of migraine headache are migraine without aura and migraine with aura. Approximately 20 percent of migraine sufferers experience aura during their migraine attacks. The aura is comprised of neurological symptoms that most often include visual disturbances, such as flashing lights or lines, and may also include dizziness, numbness, or tingling that usually precedes the headache.

Attacks are typically occasional — one to three times per month — yet sometimes they occur two or three times per week and last from four to 48 hours, and sometimes as long as 72 hours if left untreated.

Migraines can be triggered by a number of things. Triggers can be emotional, such as stress, anxiety, depression, or even mild excitement. They can also be triggered by certain foods, including alcohol, chocolate, or citrus fruits. Hormones are also common triggers — many women experience migraines with changes in their estrogen levels during menstruation, pregnancy, childbirth, and menopause.

Migraine headaches affect — and disrupt — millions of lives each year. While migraine attacks are responsible for missed family time, strained relationships, loneliness, sleep deprivation, and frustration, migraine also takes its toll on the workplace. According to the National Consumer League, migraine costs society at least $5 billion in lost productivity and 270 lost workdays for every 1,000 workers each year.

Yes. Studies have shown that the majority of migraine patients do not currently seek professional treatment.

Where can patients get more information on managing migraine headache pain?

There are many resources available, including the National Headache Foundation (1-800-843-2256), The American Headache Society (1-800-255-ACHE).

Definitely. Many people get headaches or make their headaches worse because of poor posture. If you hold your head up in proper alignment with your body, there's less strain on your muscles. But if it is held forward of its proper position, it places strain on the muscles of the neck and upper back. Certain positions can lead to muscle strain and headache if they're held for a time. If you hold a particular position such as bending over a typewriter, or holding the phone between your shoulder and your head, or doing any type of repetitive movement, you could be vulnerable to headache. One way to counteract these stresses is to change position frequently. Every 45 minutes or so, give yourself a three to five minute "break." Get up from your desk and walk to the copy machine or do some filing, anything as long as you change positions.

Sinuses are air-filled cavities (spaces) located in the forehead, cheekbones, and behind the bridge of the nose. The sinuses produce a thin mucus that drains out of the channels of the nose. When a sinus becomes inflamed, often as the result of an allergic reaction, the inflammation will prevent the outflow of mucus and cause a pain similar to that of a headache. See a doctor if you are experiencing sinus headaches to determine the cause.

Sinus headaches are associated with a deep and constant pain in the cheekbones, forehead or bridge of the nose. The pain usually intensifies with sudden head movement or straining. The pain is usually accompanied by other sinus symptoms, such as nasal discharge, feeling of fullness in the ears, fever, and facial swelling.

Whether your headache symptoms can actually be attributed to the sinuses will need to be determined by health care professionals. If your headache is caused by a sinus blockage, such as an infection, you will likely have a fever and require a prescription medication.

Treatment of sinus headaches is usually directed toward symptom relief and treating the infection. Treatment might include antibiotics for the infection, as well as a short period of pain and fever reliever (such as acetaminophen, aspirin), decongestants (such as phenylephrine, a vasoconstrictor to decrease nasal congestion), or antihistamines to treat the symptoms.

It is generally a misconception that allergies cause headaches. However, allergies can cause symptoms such as sinus congestion, which can lead to headache pain. If you have allergies, the treatment for your allergy can relieve your allergy symptoms, but may not relieve your headache pain. The two conditions often must be treated separately. See your doctor to ensure proper treatment.

Yes. The amount of sleep needed is largely influenced by age. As we grow older, not only do we require less hours of sleep, but also less deep sleep. In fact, we need half as much deep sleep in our 60s as we did in our 20s. Also, the number of awakenings during the night increases as we age. If you find yourself waking too early and feeling tired by late afternoon, try going to sleep a bit later and getting up at the same time each morning. Avoid taking naps during the daytime. Keep in mind that the amount of sleep needed for each individual varies and changes, and feeling refreshed and alert after a good night's sleep may have nothing to do with quantity — just quality of the sleep you're getting.

It is widespread. Sleep disorders affect as many as one-third of American adults. This includes 40 million people with chronic sleep problems and another 20-30 million with intermittent difficulties. Millions more are sleep deprived due to the demands and stresses of everyday living, and may be at risk for sleep difficulties since stress is a leading cause of insomnia. In women, physiological factors such as the menstrual cycle, pregnancy and postpartum, and menopause commonly interfere with sleep throughout women's lives. A government commission recently reported that sleep difficulties may affect more than 40% of women over the age of 40!

Possibly. Insomnia covers difficulty getting to sleep as well as waking up in the middle of the night and not being able to get back to sleep. While even good sleepers awaken five to 15 times each night, most fall asleep within a few seconds and forget that they have been awake. Studies show that at least half of all sleep problems are caused by such issues as marital stress, job stress, anxiety, or depression. If you are having trouble falling back to sleep, pay attention to the thoughts running through your mind. They may help you find the cause of your problem.

People who experience pain may have difficulty falling asleep and staying asleep. This can reduce the duration and quality of sleep.

Many people experience headaches on weekends and holidays. In fact, the "weekend" headache is a recognized occurrence. Altered sleep patterns may contribute to weekend headaches. If you use weekends to "sleep in," you may actually be oversleeping, and that may cause migraines in some people. Migraine headaches can begin during the stage of sleep called Rapid Eye Movement (REM). REM sleep accounts for about 25% of adult sleep time. Therefore, the more you sleep, the more REM sleep you experience, and the more likely you are to get a headache. Maintaining a consistent sleep schedule by getting up at the same time as you do during the week should help you avoid this problem.

Yes, they could. Research has shown that there is a relationship between headache activity and cigarette smoking. There is also an association between brands with higher nicotine and more frequent  occurrence of headaches. If your wife would like to quit smoking, these findings may provide the incentive she needs.

For some people, stress may be a function of everyday life. A demanding job or boss, financial, marital, or other interpersonal problems may be the rule rather than the exception. It is only during periods of relaxation such as after work or weekends when stresses are lessened that these individuals may experience headaches. These headaches are not psychological, but rather physical in nature. During times of prolonged stress, the blood vessels constrict and tighten. When the stress is gone and these people are finally able to relax, the blood vessels dilate and may result in headache. A good way to try to avoid this cycle is to attempt to minimize stressful times and try to keep busier during leisure times.

The stress response is your body's instinctive reaction to a dangerous or stressful situation. This reaction can be both helpful and harmful. For example, one of the instinctive responses to stress or danger is muscle contraction. This is helpful during times of physical stress, such as when muscles contract tightly around a broken bone to prevent further injury. But some people respond to emotional stress — such as an argument at work — with the same clenched muscles, which can lead to a painful muscle contraction headache. Look in the mirror the next time you're in a tense situation. If you see hunched shoulders, a clenched jaw and an angry look, you may be someone whose headaches are caused by a muscle contraction response to anger and worry.

There may be. TMJ syndrome is believed to be due to the misalignment of the teeth and the jaw, and the strain of the surrounding muscles used to compensate for this misalignment. In some cases, it may also be due to an arthritic condition of the joints. Some people respond to stress by clenching their jaw, or grinding their teeth both during the day as well as at night. If you suffer from TMJ syndrome and respond to stress in this way, you may actually be compounding the problem. Consider self-massage as a way to alleviate some of the stress, and see your doctor, dentist, or a TMJ specialist for further information.